Is Myasthenia Gravis the Underdiagnosed Culprit of Canine Acquired Idiopathic Megaesophagus?

SUMMARY: Researchers will analyze whether myasthenia gravis is the undiagnosed cause of acquired idiopathic megaesophagus in dogs.

THE PROBLEM: Acquired megaesophagus is a serious disease that can affect any dog breed. In this condition, the esophagus becomes enlarged and loses its ability to move food down into the stomach. Instead, food and water often come back up soon after eating. When this happens, dogs can accidentally breathe food or liquid into their lungs, which may cause life-threatening lung infections. In some dogs, acquired megaesophagus may be caused by the body mistakenly attacking its own muscles (autoimmune destruction). But in most cases, the cause is unknown, and there is no reliable cure. New treatments and better diagnostic tests could help dogs suffering from this disease.

THE PROJECT: The study team will take a closer look at the muscle of dogs who have died with and without disease to look for signs of myasthenia gravis. In addition, they’ll look for other markers of disease that could be used as new treatment targets. This same approach could also lead to new, more sensitive diagnostic tests. 

POTENTIAL IMPACT: This work could lead to earlier diagnosis, better treatment, and longer, healthier lives for dogs living with acquired megaesophagus.