Environmental Exposures and Hemangiosarcoma Risk in Dogs: A Case-Control Study Using the Golden Retriever Lifetime Study Biorepository

SUMMARY: Researchers will study the effects of exposure to environmental pollutants on the hemangiosarcoma risk in dogs enrolled in the Golden Retriever Lifetime Study.

THE PROBLEM: Hemangiosarcoma is an aggressive cancer that affects many dogs, especially golden retrievers. It is the leading cause of cancer-related deaths in the Golden Retriever Lifetime Study (GRLS), yet little is known about risk factors. Since there are no effective ways to prevent hemangiosarcoma, understanding possible risk factors is crucial.

THE PROJECT: The study aims to investigate whether exposure to environmental pollutants contributes to the development of hemangiosarcoma in dogs. Specifically, the team will analyze stored blood samples from golden retrievers enrolled in the GRLS to measure levels of chemicals known as persistent organic pollutants (POPs). These include pesticides like DDT, industrial compounds such as polychlorinated biphenyls (PCBs), and flame retardants. These chemicals can remain in the environment for decades and have been linked to cancer in humans, but their effects on canine health remain largely unknown.

The researchers will compare blood samples from 100 dogs diagnosed with hemangiosarcoma to 200 healthy age-matched golden retrievers to determine if higher levels of these chemicals are associated with the disease. Additionally, they’ll examine owner-reported data on household and environmental exposures to identify possible lifestyle risk factors related to disease status.

POTENTIAL IMPACT: This research is the first of its kind to explore environmental influences on hemangiosarcoma. By identifying potential risk factors, the team hopes to provide insights that could lead to preventive strategies and improve the long-term health of dogs. Their findings may also have broader implications for human health, as hemangiosarcoma shares similarities with a rare and aggressive human cancer known as angiosarcoma. Study results will seek to advance cancer prevention and improve the lives of our beloved canine companions.