Using Bio-Detection Dogs to Develop a New Diagnostic Test for Hemangiosarcoma

SUMMARY: Researchers will identify the volatile organic compound (VOC) profile of hemangiosarcoma using bio-detection dogs as a step toward a diagnostic test for the disease.

THE PROBLEM: Canine hemangiosarcoma (HSA) is a deadly cancer that is often diagnosed too late for effective treatment, making early detection crucial. Despite years of research, early detection of the disease remains elusive, and new approaches are needed.

THE PROJECT: This study aims to advance development of a simple, non-invasive test for HSA by identifying a specific odor fingerprint linked to the disease. Characterizing the VOC profile using analytical techniques is a vital step, providing foundational data that can benefit researchers across various disciplines. 

Trained bio-detection dogs have been able to correctly identify canine HSA blood serum samples from line-ups which included serum from healthy dogs and dogs sick with other conditions, with an average accuracy of 71%. Building on this finding, the proposed study will chemically analyze the VOCs in the blood of dogs with confirmed HSA, healthy dogs, and dogs with other illnesses. These VOCs will be recreated as synthetic odors and presented to the trained dogs to help confirm which parts of the odor are most important for detecting the disease. 

While we do not anticipate the bio-detection dogs as part of the final diagnostic test, they serve as critical biosensors in this research. Their ability to detect specific odors present in HSA will help us define the VOC signature of the disease. 

POTENTIAL IMPACT: Results could guide non-invasive tools, such as a blood test, for earlier detection and improved survival rates.